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Combined mosaic rate by month

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Written by Andrew Manderson

What this card shows

The Combined mosaic rate by month card shows the share of resulted embryos the genetics laboratory reported as mosaic. A mosaic embryo is one carrying a mixture of chromosomally normal and abnormal cells.

There are two lines:

  • Combined mosaic rate (%): the month's rate.

  • Awaiting result (%): the share of that month's embryos still with the genetics laboratory, shown as a dotted line.

Combined means all three mosaic gradings count towards it: Mosaic, High level mosaic and Low level mosaic. The Ploidy mix by month card higher up the tab deliberately keeps those three apart, so use that one when you want to see how your reports are distributed between the gradings, and this one when you want a single figure for the lot.

Reading the card

The denominator is embryos with a result returned, not every embryo biopsied. An embryo still awaiting its result cannot yet be called mosaic or not mosaic, so counting it would understate the rate.

That is a different denominator from the No result rate by month card beside it, which does include embryos still awaiting a result. The two differ on purpose, and each card states which it uses.

Even so, a recent month can still move. Embryos missing from the denominator today will join it as their results land, and the rate will shift with them. The dotted Awaiting result (%) line is plotted alongside as the warning: the taller it is in a month, the less settled that month's rate is.

  • Hover any point to read the exact rate and the counts behind it.

  • A rate that jumps in the last month or two, with the dotted line high, is usually the sample being small rather than anything changing in the laboratory.

The card sits on the PGT KPIs dashboard, on the PGT outcomes tab, and responds to the filters at the top:

  • Biopsy date: the time window. It scopes by the date the biopsy request was raised, and starts on the past 6 months plus the current month.

  • Embryologist (biopsy): pick one practitioner to see only their rate. This chart answers one practitioner at a time; the Embryologist summary table below it compares everyone at once.

  • Destination lab: the genetics laboratory the request was sent to for analysis. Laboratories do not all apply the same result definitions, so pick one to compare like with like; requests migrated from a previous system mostly carry no laboratory and drop out when you do.

  • Test types: keep only embryos whose request was sent for a particular test.

  • Clinic (patient's cycle location): focus on one or more of your locations.

Two things worth knowing about how the months and the clinic are decided:

  • Each embryo falls in the month its biopsy request was raised, not the month its result arrived. wawa does not record the date a result came back.

  • Clinic (patient's cycle location) is the clinic the patient's cycle belongs to, not the laboratory that carried out the biopsy. wawa records the laboratory a request was sent to for analysis, which is the Destination lab filter, but not which laboratory performed the biopsy itself.

Biopsy requests migrated from a previous system carry no embryologist, so they are counted here but disappear as soon as you pick a name in the Embryologist (biopsy) filter.

Where this data comes from

The rate is counted from the Chromosomal status recorded against each embryo on its biopsy record. Any of the three mosaic gradings makes the embryo part of the numerator; any status at all makes it part of the denominator.

Recording the grading the laboratory actually reported, rather than flattening everything to Mosaic, keeps the Ploidy mix by month breakdown meaningful. It makes no difference to this card, which adds the three together either way.

Opening this card

In wawa, open Insights from the sidebar, then go to Standard Reports → Laboratory Performance - Biopsies/PGT → PGT KPIs. Select the PGT outcomes tab. The Combined mosaic rate by month card is the lower right of the four charts at the top of the tab.

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